The ex-Blue Peter host hopes to have more luck spotting spooks with other channels.
She said she was leaving to "move paranormal activites to the next level".
Yvette also claimed she got buckets of fan mail asking her to to "go further and move forward".
In a letter to fans of the Living show she announced she would now be ghost-hunting for other channels including ITV2's Ghosthunting.
Yvette, 41, joked: "That's not so much goodbye as see you on the other side!"
She made the statement on the website for the show's maker Antix Productions, which she set up with her husband Karl Beattie.
It has not been decided whether Most Haunted will continue without her.
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